Journal: Oncotarget

Article Title: Role of long non-coding RNAs in disease progression of early stage unmutated chronic lymphocytic leukemia

doi: 10.18632/oncotarget.26538

Figure Lengend Snippet: FC in (A) lncRNA and (B) mRNA expression.

Article Snippet: RNA was submitted to Arraystar Inc. (Rockville, MD, USA) for lncRNA and mRNA expression profiling and data analysis.

Techniques: Expressing

Journal: Cancers

Article Title: Genome-Wide Analysis of lncRNA-mRNA Co-Expression Networks in CD133+/CD44+ Stem-like PDAC Cells

doi: 10.3390/cancers15041053

Figure Lengend Snippet: Construction of lncRNA-mRNA/lncRNA co-expression networks via IPA & clinicopathological correlations with the selected lncRNAs. ( A – C ) The construction of the lncRNA-mRNA/lncRNA co-expression networks revealed seven lncRNAs interacting with other lncRNAs or hub nearby mRNAs, known to be involved in CSC pathophysiology, namely ATF2, PRKCE, CHEK1, SNHG6, DEDD2, DCAF8, and PAX8 (all circled). The identified network functions are associated with “cell cycle, cell death and survival, and cellular movement” (network 1; ( A )), “cell death and survival, cell cycle, and tissue morphology” (network 2; ( B )) and “dermatological diseases and conditions, developmental disorder, and hereditary disorder” (network 3; ( C )). ( D – H ) In silico analysis of RNA-seq data from the TCGA-PAAD project of The Cancer Genome Atlas was used for establishing gene expression differences ( D ) between PDAC and normal tissues, as well as associations with clinicopathological characteristics, including ( E ) cancer stage and ( F ) grade, ( G ) lymph node metastasis (N0/N1 nodal status) and ( H ) overall survival (depicted by Kaplan–Meier curves). The asterisk (*) indicates that a given gene is represented with multiple symbols.

Article Snippet: Whole genome mRNA and lncRNA raw expression data for this study were generated by ArrayStar Inc. (Rockville, MD).

Techniques: Expressing, In Silico, RNA Sequencing, Gene Expression